Regarding the VHF/UHF radio, just make sure that your local operators are indeed using DMR, not Fusion or Dstar. It seems that different locales use different digital modes. In the northeast it seems that DMR is the primary mode. In the southeast it's Dstar for the most part. I ended up going the Dstar route because I have so many Dstar portables, and I also have a couple of HF radios that are Dstar capable too.
For those on a budget, I'd say that a DMR radio is the way to go because their prices have dropped dramatically.
I have used a FT-817 with a Signalink and it worked okay. I sold the Signalink once I acquired an Icom IC-7200 which has a soundcard built in and it just requires a USB cable to directly interface with my laptop. All of the newer Icoms have that capability and it eliminates extra cables and one additional possible point of failure.
One other note, when using HF digital modes, make sure your computer is capable of handling the software. This past weekend I spent some time trying to get an Icom IC-9100 to run digital modes on a Dell Netbook. Unfortunately the Netbook runs Windows XP, and it runs slower than heck. I ended up temporarily abandoning the project until a replacement CF-30 Toughbook arrives loaded with Windows 7. Hopefully, the Toughbook will load up properly.