Author Topic: Ebola Update via Someone in the Know  (Read 1074 times)

Offline JohnyMac

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Ebola Update via Someone in the Know
« on: May 23, 2019, 09:00:04 AM »
Good update on Ebola today from NC Scout over at American Partisan titled, Ebola Update via Someone in the Know.
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Offline Nemo

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Re: Ebola Update via Someone in the Know
« Reply #1 on: May 23, 2019, 10:48:13 PM »
Yeps.  Like I been saying.

Nemo


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Offline Kbop

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Re: Ebola Update via Someone in the Know
« Reply #2 on: May 24, 2019, 06:50:43 AM »
measles meet ebola -
 :zombie1:

Offline patriotman

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Re: Ebola Update via Someone in the Know
« Reply #3 on: May 24, 2019, 08:20:12 AM »
Blessed be the LORD my strength, which teacheth my hands to war, and my fingers to fight: My goodness, and my fortress; my high tower, and my deliverer; my shield, and he in whom I trust; who subdueth my people under me.

Psalm 144:1-2

Offline JohnyMac

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Re: Ebola Update via Someone in the Know
« Reply #4 on: May 24, 2019, 09:17:27 AM »
Erick, I know you are traveling but would you comment? Thx
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Offline Erick

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Re: Ebola Update via Someone in the Know
« Reply #5 on: May 24, 2019, 10:35:24 AM »
Erick, I know you are traveling but would you comment? Thx

Ok I'll bite. I am teaching a class on this subject this very summer.

Nothing that was written in the linked short article was outright incorrect.
The trick is in the nuances.

I've written about this back over 5 years ago that certain newer strains (best example the one that come out in late 2013 and broke into public's consciousness around April 2014) can be asymptomatic yet infectious..
This window is small but it does exist with some strains such as that one.
So that much is true.

Up until that point one could generally rely on asymptomatic would equal no infectiousness..

But lets explain the difference between "infectiousness" and "transmissible"

Infectiousness refers to the ease (or lack thereof) with which a given pathogen (in this example a EBOV virion) can make a given person sick ("infect them")
"transmissibility" refers to the ability of a pathogen to travel between likely hosts.

So for a successful spread of a disease the pathogen has to be first transmitted and before it can infect.

Ebola is very infectious but not very transmissible at all.
This is because it is so fragile.

As a result it forms the necessary "fomites" (infectious matter in the environment, like on a table etc) only very poorly.
Despite the occasional published number of "weeks" in the environment.. (thats a worst case number if it is protected from drying out from air, protected from sunlight, protected from large changes in ph..this is really only possible if a drolet of blood goes deep into a pore of untreated wooden building material, its not common at all).... the real number are in open air in daytime it will "die" (lose infectiousness) in as little as a couple of minutes.
Nighttime maybe a half hour (could be less)

That is why looking at Ebola or other VHF as a major public health threat for the developed world is a barking up the wrong tree..

For example even if a person is infected yet asymptomatic (a small window) it does not mean this person can transmit his pathogen in any meaningful way short of very close personal contact (sex).

The main transmission mechanism for VHF is Blood, vomit, feces (diarrhea) and cough droplets and all of those are tied to symptoms of the full blown disease.
So is it possible to infect asymptomatic?
Yes.
Will it  be commonplace enough to enable an outbreak to go pandemic?
No.

Flu strains are much more likely to be a global pandemic threat because they are so transmissible and that is even more important than infectiousness.
Flu is both highly transmissible (it "survives" drying out which can make it airborne) robust, and infectious.. Its just not very lethal (compared to the VHFs) right now.

If you ever want to learn a realistic pandemic response and about a likely (natural) creation of said pathogen watch the movie "Contagion"
« Last Edit: May 25, 2019, 03:19:28 AM by Erick »
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Offline JohnyMac

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Re: Ebola Update via Someone in the Know
« Reply #6 on: May 24, 2019, 08:12:36 PM »
That was awesome Erick!

UP is so grateful to have you part of the forum.  :cheers:
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Offline Erick

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Re: Ebola Update via Someone in the Know
« Reply #7 on: May 25, 2019, 02:44:01 AM »
That was awesome Erick!

UP is so grateful to have you part of the forum.  :cheers:

Thanks for the kind words. I edited typos and grammar a bit for clarity :)
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gadget99

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Re: Ebola Update via Someone in the Know
« Reply #8 on: May 25, 2019, 03:20:42 AM »
As usual Erik you provide such a valuable voice of clarity on these subjects.

Thank you for educating us.

Cheers

Offline JoJo

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Re: Ebola Update via Someone in the Know
« Reply #9 on: May 25, 2019, 09:38:18 AM »
 This is the reason I love UP, the fact that there are people on this board who are in the know and tell us with any BS. Thank You Eric and all of you for the information you give us. :cheers:
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Offline Erick

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Re: Ebola Update via Someone in the Know
« Reply #10 on: May 26, 2019, 02:53:46 PM »
... thanks fellas for all the kind words..  :dance:
« Last Edit: May 26, 2019, 03:11:21 PM by Erick »
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Offline Nemo

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Re: Ebola Update via Someone in the Know
« Reply #11 on: May 26, 2019, 04:38:49 PM »
Good, I feel a fair bit unscrewed now.

Nemo
If you need a second magazine, its time to call in air support.

God created Man, Col. Sam Colt made him equal, John Moses Browning turned equality to perfection, Gaston Glock turned perfection into plastic fantastic junk.

Offline patriotman

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Re: Ebola Update via Someone in the Know
« Reply #12 on: May 28, 2019, 07:40:34 AM »
Now what happens if someone was able to modify the strain and make it more transmissable? I mean, this is movie level stuff, but is that in theory possible?
Blessed be the LORD my strength, which teacheth my hands to war, and my fingers to fight: My goodness, and my fortress; my high tower, and my deliverer; my shield, and he in whom I trust; who subdueth my people under me.

Psalm 144:1-2

Offline Nemo

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Re: Ebola Update via Someone in the Know
« Reply #13 on: May 28, 2019, 08:05:17 AM »
Then we are tripled up.

Nemo
If you need a second magazine, its time to call in air support.

God created Man, Col. Sam Colt made him equal, John Moses Browning turned equality to perfection, Gaston Glock turned perfection into plastic fantastic junk.

Offline Erick

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Re: Ebola Update via Someone in the Know
« Reply #14 on: May 29, 2019, 12:31:59 AM »
Now what happens if someone was able to modify the strain and make it more transmissable? I mean, this is movie level stuff, but is that in theory possible?

You have to change the fundamental nature of your VHF pathogen, its structure and composition is what makes it fragile in the environment and so greatly lowers its potential for transmission..
A mere tweak wont do it.

It would be a easier to "soup up" a flu virus since u'd have to change so much less about it.
Still requires nation state level expertise  to determine whats your "best" modification... a couple of terrorists in a cave arent doing this.

Or,.... since the genome of smallpox has been published .. nowadays you could assemble at least in theory the actual virus from that (with some skill and effort... but its possible unlike say 25 yrs ago when the enzymatic tools to string up nucleic acids,  and then to then translate the nucleic acids into proteins.. did not exist the way they do now..... I have never done this.. but I know people have done different parts of this independently on other "bugs")

This latter should be available to any large and well equipped University laboratory
« Last Edit: May 29, 2019, 12:40:16 AM by Erick »
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Offline patriotman

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Re: Ebola Update via Someone in the Know
« Reply #15 on: May 29, 2019, 05:56:39 AM »
Thanks for explaining. I am definitely less worried than I was, though the ability to reengineer a flu virus is also a terrifying thought.

If someone manages to infiltrate the university system....
Blessed be the LORD my strength, which teacheth my hands to war, and my fingers to fight: My goodness, and my fortress; my high tower, and my deliverer; my shield, and he in whom I trust; who subdueth my people under me.

Psalm 144:1-2