To bug in or bug out? Would depend on what the emergency is, how much time you have and where you are when it happens. Lots of people prep for an economic collapse, or civil unrest, or government take over. While these may happen at some point, a natural disaster should also be in the mix. The worst that could happen is probably a fire, because it will destroy everything we have set up. For bugging out, what scenarios would force you from your house? Flood, gas leak, tornado, fire (thinking it will never happen to us, but maybe the neighbors house burns and catches your house on fire), nuclear leak, industrial accident-chemical leak. There are others, but all of these could force you from your home. If you have a secondary property to go to that you have stocked up, you are in good shape. If not, you will likely have only what you can carry on your back, or in your vehicle, or what you have with you if you were not home at the time of the event. After the event, if you have to go to an aid area, camp or whatever, you will not be welcome if you are carrying a visible weapon. Maybe arrested or turned away. Lots to think about.
For me, a fire would be the worst. Happens too fast and would likely destroy everything I have set up. I do have a storage unit across town with 2 cars and some gear in it, but not much. Yes I have friends, am well insured and would be fine in a localized event. A major disaster, war, big earthquake and so on would be harder.
Be realistic in your thinking. What could you carry? How far could you carry it? To carry a weapon and a large amount of ammo is not realistic, except for a 22. Water weighs a lot, canned food weighs a lot, we need to be able to source clean water somehow and carry/store some of it.Beef jerky is easy to carry, long lasting and takes a while to eat. Protection from elements, rain gear, cold weather, sun, tent/bivy, sleeping bag and plastic sheeting. Medications. The list goes on. A 100 pound pack/bag is not realistic. 30 to 50 pounds is. Even a suitcase on rollers is usable if you are on concrete or a small cart if you physically can't carry a bag.